Oxygen resuscitation and oxidative-stress biomarkers in premature infants
نویسندگان
چکیده
منابع مشابه
Resuscitation of Preterm Infants with Reduced Oxygen Results in Less Oxidative Stress than Resuscitation with 100% Oxygen
The objective of this study was to determine the effects of the level of inhaled oxygen during resuscitation on the levels of free radicals and anti-oxidative capacity in the heparinized venous blood of preterm infants. Forty four preterm infants <35 weeks of gestation with mild to moderate neonatal asphyxia were randomized into two groups. The first group of infants were resuscitated with 100%...
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OBJECTIVES. Inhaled nitric oxide treatment for ventilated premature infants improves survival without bronchopulmonary dysplasia. However, there has been no information regarding possible effects of this therapy on oxidative stress. We hypothesized that inhaled nitric oxide therapy would not influence concentrations of plasma biomarkers of oxidative stress. PATIENTS AND METHODS.As part of the N...
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Premature infants < 32 weeks’ gestation often require resuscitation during fetal to neonatal transition, which includes administration of supplemental oxygen. Hyperoxia is one of the important generators of reactive oxygen species (ROS) and excess ROS is kept in check by antioxidant defense mechanisms. Premature infants have reduced antioxidant defense mechanisms at birth and hence are at risk ...
متن کاملOptimal oxygen saturation in premature infants
There is a delicate balance between too little and too much supplemental oxygen exposure in premature infants. Since underuse and overuse of supplemental oxygen can harm premature infants, oxygen saturation levels must be monitored and kept at less than 95% to prevent reactive oxygen species-related diseases, such as retinopathy of prematurity and bronchopulmonary dysplasia. At the same time, d...
متن کاملMaintaining optimal oxygen saturation in premature infants.
INTRODUCTION Advances in technology have resulted in increasing survival rates for premature infants. Oxygen therapy is commonly used in neonatal units as part of respiratory support. The number of premature infants in our institution surviving with severe (stage ≥3) retinopathy of prematurity (ROP) prompted a review of oxygen therapy as a contributing factor. Prolonged exposure to high concent...
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ژورنال
عنوان ژورنال: Research and Reports in Neonatology
سال: 2014
ISSN: 1179-9935
DOI: 10.2147/rrn.s62679